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Abstract #2669

Lateralisation of the connections between Broca's area and the pre-SMA in relation to handedness

Henrietta Howells 1 , Flavio Dell'Acqua 2,3 , Anoushka Leslie 2 , Michel Thiebaut de Schotten 1,4 , Mitul Mehta 2 , Declan G. Murphy 1 , Andrew Simmons 2 , and Marco Catani 1

1 Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, United Kingdom, 2 Department of Neuroimaging, Institute of Psychiatry, London, United Kingdom, 3 NIHR Biomedical Research Centre for Mental Health at SLAM NHS Foundation Trust, Institute of Psychiatry, London, United Kingdom, 4 Universit Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle pinire, Paris, France

The frontal aslant tract (FAT) is a newly described pathway connecting posterior Broca's territory with the pre-SMA and cingulate cortex. This tract is significantly left-lateralised in right-handed subjects and plays a role in speech initiation. It has not yet been studied in left-handers. We used spherical deconvolution diffusion tractography to compare this tract in right and left-handed subjects, finding left-lateralisation was not significant in the left-handed group. This may be reflective of more heterogeneous patterns of functional activation for language in left-handed individuals.

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