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Abstract #2679

Double-Pulsed-Field-Gradient MRI at long mixing time of global hypoxia

Darya Morozov 1 , Debbie Anaby 1 , and Yoram Cohen 1,2

1 School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Science, Tel-Aviv University, Tel-Aviv, Ramat-Aviv, Israel, 2 Sagol School of Neurosciences, Tel-Aviv University, Tel-Aviv, Ramat-Aviv, Israel

Diffusion weighted MRI and DTI, have been extensively used to study pathologies and to perform non-invasive in vivo tractography of the CNS. However, the ADC, FA and MD extracted from DWI and DTI experiments have limited sensitivity and specificity to structural changes. Therefore there is a constant need to develop new potential methods to provide more specific microstructural indices. In the present work we study the effect of global hypoxia on the indices extracted from angular d-PFG MRI at a long mixing time and compare them with the changes observed in the FA and MD obtained from DTI.

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