Abstract #2710

Signal-to-noise ratio of perfusion mapping using multiphase pseudocontinuous arterial spin-labeling MRI

Wen-Chau Wu ^1,2 , Shu-Fen Jiang ³ , and Shu-Hua Lien ³

¹ Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, ² Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ³ Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

In pseudocontinuous arterial spin-labeling (PCASL), labeling efficiency ( lower case Greek alpha

) is sensitive to field inhomogeneity. Multiphase PCASL (MP-PCASL) calibrates lower case Greek alpha

by tracking image intensities with varied phase offsets ( lower case Greek phi

) in the labeling pulses. In the present study, we investigated the feasibility of generating flow maps by combining the MP-PCASL images obtained at a subset of lower case Greek phi

's. Results show that the measurements of individual lower case Greek phi

's in MP-PCASL can be combined to provide perfusion mapping with an SNR greater than or equal to

0.6-fold of the value provided by single-phase PCASL. The gain of SNR is expected to appear when the background-induced phase exceeds 50 ⁰ .

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