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Abstract #2722

Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with 15 O H 2 O positron emission tomography

Dennis F R Heijtel 1 , Henri J M M Mutsaerts 1 , Esther Bakker 2 , Patrick Schober 3 , Markus F Stevens 4 , Esben T Petersen 5 , Bart N M van Berckel 2 , Charles B L M Majoie 1 , Jan Booij 6 , Matthias J P van Osch 7 , Ed T vanBavel 8 , Ronald Boellaard 2 , Adriaan A Lammertsma 2 , and Aart J Nederveen 1

1 Radiology, Academic Medical Center, Amsterdam, Netherlands, 2 Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, 3 Anesthesiology, VU University Medical Center, Amsterdam, Netherlands, 4 Anesthesiology, Academic Medical Center, Amsterdam, Netherlands, 5 Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 6 Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, 7 C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands, 8 Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

In this study we assessed the accuracy and precision of quantitative pCASL-based CBF and CVR measurements by performing a head-to-head comparison with 15 O H 2 O PET, based on quantitative CBF measurements during baseline and hypercapnia. We demonstrate that pCASL CBF imaging is accurate during both baseline and hypercapnia with a precision comparable to 15 O H 2 O PET.

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