Mapping blood volume fraction and vessel size index at steady-state: Impact of contrast agent dose and spin-echo time
Benjamin Lemasson 1 , Nicolas Pannetier 2 , Thomas Christen 3 , Greg Zaharchuk 3 , Norbert Schuff 2 , and Emmanuel Barbier 1
U836, Iserm, Grenoble, France,
medical center, Centre for neurodegenerative des eases,
San Francisco, CA, United States,
University, Department of Radiology, Stanford, CA,
Cerebral blood volume fraction (BVf) and vessel size
index (VSI) can be mapped with a steady-state approach.
To optimize the protocol in the brain, we evaluated the
impact of three different doses of contrast agent and
three different MRI sequences on the results obtained in
healthy rats (n=5). When mapping BVf and VSI at 4.7T,
the use of an echo time beyond 60ms decreases the CNR.
Regarding the CA dose, no significant changes has been
observed on BVf map whereas the use of 200mol of Fe/kg
yields the best CNR at the Spin-echo time but two-third
of the dose appears almost equivalent in term of CNR.
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