Abstract #2740
Investigation of Weighted Fits applied to Compartment Models of Dynamic Contrast Enhanced Magnetic Resonance Imaging
Frank G Zoellner 1 , Philip Schmidt 1 , and Lothar R Schad 1
1
Computer Assisted Clinical Medicine, Medical
Faculty Mannheim, Heidelberg University, Mannheim,
Baden-Wuerttemberg, Germany
Dynamic contrast enhanced magnetic resonance imaging
(DCE-MRI) in conjunction with pharmacokinetic modelling
can be used to assess physiological parameters like
perfusion and permeability. The aim of this study was to
investigate the effect of weighted fits applied to
DCE-MRI data, using both simulated and measured samples,
and the overall goal was to quantify if weighting leads
to a better fit performance.It could be shown that in
most of the studied tissues the errors of the fit
parameters decreased when linear weights were applied.
Initial results of the in vivo data of the rat shown
made clear that weighting has a small but positive
effect on the fit performance in living tissue
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