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Abstract #2743

Comparison of contrast concentration conversion methods for pharmacokinetic analysis of Dynamic Contrast Enhanced (DCE) MRI in the thin vessel wall: T1 mapping is not worthwhile by introducing more variance

Tingting Wu 1 , Jinnan Wang 2 , Yan Song 3 , Xiaotao Deng 3 , Xihai Zhao 1 , Rui Li 1 , Anqi Li 3 , Shuo Chen 1 , Chun Yuan 1,4 , and Huijun Chen 1

1 Center for Biomedical Imaging Research, Tsinghua University, Beijing, Beijing, China, 2 Philips Research North America, Briarcliff Manor, New York, United States, 3 Beijing Hospital, Beijing, China, 4 Dept. of Radiology, University of Washington, Seattle, Washington, United States

We evaluated the reproducibility of pharmacokinetic measurement by using contrast concentration conversion with pre-T1 mapping in DCE-MRI of experimental thin vessel wall (thickness < 1mm). We found that concentration conversion with pre-T1 mapping has poorest reproducibility, compared with normalized intensity curves and contrast concentration conversion with fixed pre-T1. Thus, adding pre-T1 mapping for concentration conversion in the analysis of DCE-MRI is not worthwhile on thin vessel wall imaging. Both concentration conversion with assumed pre-T1 or directly using the normalized signal curves are more preferable.

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