Abstract #2746
Assessment of Scan-Rescan Variability in DCE-MRI Parameters Using Multiple Models
Edward Ashton 1 , Jean Tessier 2 , and Oliver Krieter 3
1
Imaging Science, VirtualScopics, Inc.,
Rochester, NY, United States,
2
F.
Hoffman-La Roche Ltd., Basel, Switzerland,
3
Roche
Diagnostics GmbH, Penzberg, Germany
This study examines the scan-rescan variability of five
parameters obtainable from DCE-MRI scans. The analysis
models examined are the Standard Tofts, Extended Tofts,
and Distributed Parameter. Two model-free parameters are
also reviewed. Data were acquired from six GBM patients,
each scanned twice within a single week. Coefficients of
variability were calculated for each of six parameters:
KTrans (Standard Tofts), KTrans (Extended Tofts), PS
(Distributed Parameter), as well as IAUC90 and AUCBN90,
which do not require an analysis model. Results show
KTrans (Standard) and AUCBN90 to be the least variable
assessments, while PS shows the highest variability of
the parameters studied.
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