Quantification of subtle blood-brain barrier permeability in white matter using DCE-MRI
Anna K Heye 1 , Michael J Thrippleton 1 , Maria del C Valds Hernndez 1 , Paul A Armitage 2 , and Joanna M Wardlaw 1
Brain Research Imaging Centre, Division of
Neuroimaging Sciences, University of Edinburgh,
Edinburgh, Scotland, United Kingdom,
Unit of Radiology, Department of Cardiovascular Science,
Medical School, University of Sheffield, Sheffield,
England, United Kingdom
This study uses T1-weighted DCE-MRI to quantify subtle
blood-brain barrier permeability in normal-appearing
white matter and white matter lesions of patients with
mild stroke. We calculated Patlaks pharmacokinetic
parameters and two model-free measurements, all of which
suggest that permeability is enhanced in white matter
lesions when compared to normal-appearing white matter.
Moreover, we investigated the relationship between
model-free and pharmacokinetic parameters, showing
moderate to strong correlations.
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