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Abstract #2751

DCE-MRI and T 2 * Measurement in Women with Heavy Menstrual Bleeding Treated with Dexamathasone

Lucy E Kershaw 1 , Gillian MacNaught 2 , Mayank Serge Madhra 3 , Hilary O Critchley 3 , and Scott IK Semple 2

1 Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, Gtr Manchester, United Kingdom, 2 CRIC, University of Edinburgh, Edinburgh, United Kingdom, 3 MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom

The aim of this study was to develop a DCE-MRI and T2* measurement protocol for monitoring dexamethasone therapy in women with heavy menstrual bleeding. A high spatial resolution protocol was developed that differentiated between inner and outer myometrium. Uptake curves could be markedly different in shape between patients, but T2* and DCE-MRI parameters were found to be similar to those described in previous work. No significant differences were found pre and post therapy but quantitative blood loss is not yet available for correlation with the measured parameters.

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