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Abstract #2759

Combined evaluation of 18 F-FDG PET Metabolic Parameters and MRI Perfusion Parameters for the Prediction of Neoadjuvant Chemotherapy Response in Osteosarcoma

In ok Ko 1 , Byung Hyun Byun 2 , Ji-ae Park 1 , Kyeong Min Kim 1 , and Sang Moo Lim 2

1 Korea Institute of Radiological & Medical Science, seoul, nowon-gu, Korea, Democratic People's Republic of, 2 Department of Nuclear Medicine, Korea Institute of Radiological & Medical Science, seoul, nowon-gu, Korea, Democratic People's Republic of

We evaluated the potentials of 18F-FDG PET metabolic parameters and dynamic contrast-enhanced (DCE) MRI perfusion parameters to predict the histologic response after neoadjuvant chemotherapy before surgery in patients with osteoscarcoma, using sequential PET/CT and MR imaging system. The cutoff values, sensitivity, specificity, and accuracy for predicting good histologic response were < 5, 92%, 58%, and 75%, respectively, for SUV max from the 18F-FDG PET after neoadjuvant chemotherapy and < 0.03 min-1, 58%, 83%, and 71%, respectively, for K trans from the DCE-MRI after neoadjuvant chemotherapy. By using the combined criterion of SUV max < 5 and K trans < 0.03 min -1 , sensitivity, specificity, and accuracy were 67%, 100% and 84%, respectively. Our results suggest that combining 18F-FDG PET metabolic parameters and DCE-MRI perfusion parameters should be an effective method to predict the histologic response to NAC in osteosarcoma.

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