Abstract #2763
Dynamic Hyperpolarized 13 C MRS in a Spontaneous Mouse Model of Thymic Lymphoma
Marc S Ramirez 1 , Jaehyuk Lee 1 , Avinashnarayan Venkatanarayan 2 , Elsa R Flores 2 , and James A Bankson 1
1
Department of Imaging Physics, The
University of Texas M.D. Anderson Cancer Center,
Houston, TX, United States,
2
Department
of Biochemistry and Molecular Biology, The University of
Texas M.D. Anderson Cancer Center, Houston, TX, United
States
In this work, we evaluate the initial feasibility of
detecting elevated aerobic glycolysis in a spontaneous
transgenic mouse model of thymic lymphoma, which is
challenging due to the close proximity of the thymus to
the heart, where high levels of pyruvate and its
metabolites could confound data analysis. Dynamic MRS
using hyperpolarized [1-
13
C] pyruvate was
performed on p53-/- mice at various stages of disease
progression. High correlation between tumor volume and
normalized lactate confirms that hyperpolarized
measurements are indeed modulated by tumor metabolism,
establishing the initial feasibility for metabolic
investigations in a spontaneous transgenic model of
lymphoma.
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