High Resolution Imaging of pH in an Isolated Perfused Rat with Hyperpolarized Bicarbonate Produced via Chemical Reaction
Rajat K. Ghosh 1 , Stephen J. Kadlecek 1 , Mehrdad Pourfathi 1 , and Rahim R. Rizi 1
University of Pennsylvania, Philadelphia,
PA, United States
Synopsis: Several medical conditions such as acute lung
injury, cancer, ischemia, and inflammation result in
alterations to the acid-base balance in tissue.
Hyperpolarized bicarbonate has been able to determine
the pH in-vivo. However the highest polarization of
bicarbonate is achieved using cesium salts. This is not
translatable to a clinical setting, as cesium ions are
highly toxic. We generate hyperpolarized bicarbonate by
decarboxylating the hyperpolarized pyruvate. This leads
to a high polarization without the use of cesium, and
allows for increased imaging resolution. We demonstrate
imaging with 1.2mmx1.2mm in plane resolution, which
could be increased to 0.5mmx0.5mm.
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