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Abstract #2772

Thermal T 1 measurements for frequently used 13 C hyperpolarization agents at clinically available field strengths

Stephan Dwel 1,2 , Patrick Christ 1,3 , Ulrich Kllisch 1,3 , Markus Durst 1,3 , Concetta V Gringeri 3,4 , Franz Schilling 4 , Marion I Menzel 3 , Rolf F Schulte 3 , Steffen Glaser 2 , Markus Schwaiger 4 , and Axel Haase 1

1 Institute of Medical Engineering, Technische Universitt Mnchen, Garching, Germany, 2 Department of Chemistry, Technische Universitt Mnchen, Garching, Germany, 3 GE Global Research, Garching, Germany, 4 Institute of Nuclear Medicine, Klinikum Rechts der Isar, Munich, Germany

Through hyperpolarized 13 C MRSI, the labeled compounds pyruvate, alanine, lactate, urea and acetate allow real-time in-vivo studies of energy metabolism, perfusion and short chain fatty acid metabolism, respectively. In hyperpolarized experiments, the signal-to-noise-ratio is independent of the magnetic field strength B 0 , but spectral resolution and spin-lattice relaxation times T 1 can strongly depend on B 0 . We measured T 1 for the five aforementioned compounds at clinically available field strengths (1T, 3T, 7T) and 14T with constant pH and temperature in a buffer solution. Within the statistical uncertainty, T 1 decreases with increasing B 0 for all substances, but the degree depends on the compound.

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