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Abstract #2777

In vivo real time metabolic imaging using frequency selective bSSFP and hyperpolarized compounds

Najat Salameh 1 , Jean-Nol Hyacinthe 2 , Andrea Capozzi 1 , and Arnaud Comment 1
1 Institut de Physique des Systmes Biologiques, cole Polytechnique Fdrale de Lausanne, Lausanne, Lausanne, Switzerland, 2 Haute cole de Sant, University of Applied Sciences Western Switzerland, Geneva, Switzerland

The specific constraints of hyperpolarized (HP) MRI are linked to the single-shot nature of the experiments due to the polarization decay. Several acquisition strategies have been developed to rapidly image the spatial distribution of multiple compounds in order to track the metabolism of HP substrates in vivo. Some techniques use RF pulses properties for interleaved acquisition of different substrates by frequency-specific excitation, whereas other approaches use the inherent frequency selectivity of MRI sequences using multi-echo or SSFP-based techniques. From these developments, we propose an improved strategy for real time imaging of HP substrates and metabolites in mice brain and liver.

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