Determination of Diffusive and Transport Processes of Hyperpolarized [1,1,2,2-D 4 , 1- 13 C]-Choline in the Rat Kidney
Trevor P. Wade 1,2 , Lanette Friesen-Waldner 2 , Curtis N. Wiens 3 , Kevin J. Sinclair 2 , Rachel Katz-Brull 4,5 , and Charles A. McKenzie 1,2
Robarts Research Institute, The University
of Western Ontario, London, Ontario, Canada,
Biophysics, The University of Western Ontario, London,
Radiology, University of
Wisconsin, Madison, WI, United States,
Hadassah-Hebrew University Medical Center, Jerusalem,
Ltd., Tel-Aviv, Israel
Choline is important in cellular membrane construction,
so there is interest in developing an MRI choline
molecular probe. This study determined if uptake of
(CMP1) in rat kidneys is due to a saturable cellular
transport process or an extracellular diffusion process.
Dynamic, 1D images of rat kidneys were obtained after
injection of four different doses of CMP1. If CMP1
uptake in kidneys was due solely to diffusion, the
kidney signal would increase linearly with
concentration. Instead, it began to plateau. This
implies a saturable transport process occurs, and uptake
is not limited to diffusion.
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