Suppression of unwanted resonances in hyperpolarized MR studies with neat [1- 13 C]lactic acid
Cornelius von Morze 1 , Peder EZ Larson 1 , Hong Shang 1 , and Daniel B Vigneron 1
Dept. of Radiology & Biomedical Imaging,
UCSF, San Francisco, CA, United States
Similar to pyruvate, neat [
appears to be the best form of lactate for dissolution
DNP. Unfortunately the neat acid is prone to form a
lactide dimer which overlaps spectrally onto product
alanine. We investigated the use of a spectrally
selective pre-saturation pulse sequence to eliminate
dimer signal prior to hyperpolarized metabolic
experiments in vivo.
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