Abstract #2795
Solvent effects of hyperpolarization drugs using signal amplification by reversible exchange (SABRE)
Haifeng Zeng 1,2 , Jiadi Xu 1,2 , Joseph Gillen 1,2 , Michael T. McMahon 1,2 , Dmitri Artemov 2 , Jean-Max Tyburn 3 , Joost A.B. Lohman 4 , Ryan Mewis 5 , Kevin D. Atkinson 5 , Gary G.R. Green 5 , Simon B. Duckett 5 , and Peter C.M. van Zijl 1,2
1
Kirby Center, Kennedy Krieger Institute,
Baltimore, MD, United States,
2
Department
of Radiology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
3
Bruker
BioSpin GmbH, Silberstreifen, Rheinstetten, Germany,
4
Bruker
UK Limited, Banner Lane, Coventry, United Kingdom,
5
Department
of Chemistry, University of York, Heslington, York,
United Kingdom
Hyperpolarization can provide improved sensitivity for
NMR, recently enabling the real-time monitoring of
metabolism in vivo. Among the parahydrogen polarization
techniques, the signal amplification by reversible
exchange (SABRE) approach does not require chemical
modification of substrate to polarize. Traditionally,
methanol-d4 was used as solvent, which is not suitable
for injection into animals. We therefore investigated
the possibility of SABRE polarization in more compatible
solvents namely DMSO, ethanol and water. In this work,
we polarized 3-amino-1,2,4-triazine, pyrazinamide and
isoniazid. In methanol-d4, up to -1400 times enhancement
was obtained, corresponding to 8% polarization. In
water, up to -65 times enhancement was obtained.
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