In-vivo tracking of 19 F-labeled natural killer cells with MRI in lymphoid tumor model
Kai D. Ludwig 1 , Jeremy W. Gordon 1 , Myriam N. Bouchlaka 2 , Christian M. Capitini 2 , Bryan P. Bednarz 1,3 , and Sean B. Fain 1,3
Medical Physics, University of
Wisconsin-Madison, Madison, Wisconsin, United States,
University of Wisconsin-Madison, Madison, Wisconsin,
Radiology, University of
Wisconsin-Madison, Madison, Wisconsin, United States
Tumor-specific immunotherapy is emerging as a novel
treatment paradigm for patients with metastatic tumors
that are incurable with conventional therapies. Natural
killer (NK) cells have shown anti-tumor effects against
hematological and non-hematological cancers. Often, lack
of knowledge on trafficking patterns limits the efficacy
of adoptively transferred NK cells anti-tumor response.
We propose to use an MRI tracer perfluoropolyether agent
to detect immune cells in-vivo. Isolated,
NK cells were injected into a mouse and
MRI detected signal accumulation in a lymphoid tumor.
signal contamination was observed from isoflurane
anesthetic requiring ketamine/xylazine as an anesthetic
in future work.
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