MEMRI of diabetic retinas during light and dark adaptation at 11.7T
Bryan H De La Garza 1 , Chakradhar Velagapudi 2 , Hanna E Abboud 2 , Guang Li 1 , and Timothy Q Duong 1
Research Imaging Institute, Department of
Radiology/Ophthalmology, Univ. Of Texas Health Science
Center, San Antonio, Tx, United States,
of Medicine-Renal Diseases, Univ of Texas Health Science
Center, San Antonio, Tx, United States
Manganese-enhanced MRI (MEMRI) was used to investigate
the calcium activity in different layers of the retina
of diabetic retinopathy (DR) rats under light and dark
adaptation 14 and 30 days after streptozocin injection.
In normals, dark adaption lowered inner retina MEMRI
activity, increased outer retina activity, but did not
affect the choroid when compared to light adaptation. In
DR rats compared to controls, MEMRI revealed reduced Mn
uptake in the inner, outer, and choroid layers.
Differential reduced MEMRI activity in dark was observed
in the outer layer in DR rats compared to controls,
suggesting outer retina dysfunction at early DR
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