Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging
Sophie Laurent 1 , Dimitri Stanicki 1 , Sebastien Boutry 2 , Ludivine Wacheul 2 , Emilien Nicolas 2 , Deborah Crombez 1 , Luce Vander Elst 1 , Denis Lafontaine 2,3 , and Robert N Muller 1,2
General, Organic and Biomedial Chemistry,
NMR and Molecular Imaging Laboratory, UMONS, MONS,
for Microscopy and Molecular Imaging, Hainaut, Belgium,
of RNA Metabolism, ULB, Brussels, Belgium
This study reports the synthesis of USPIO as bimodal
probes for magnetic resonance and optical imaging. These
nanosystems are based on small iron oxide cores
surrounded by a thin polysiloxane shell exhibiting
carboxylic acid functions. Thanks to these functions,
hybrid particles were obtained by conjugating a
fluorophore to the superparamagnetic contrastophore.
Such modification allowed directly following these USPIO
in cellulo, which provided interesting information about
their internalization pathway and cellular distribution
upon mitosis. Finally, their efficiency as probes for
bimodal imaging was emphasized by the observation of
their in vivo behavior in mice using magnetic resonance
and optical imaging.
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