Abstract #2853
Hexameric Mn(II)-EDTA Complex as Contrast agent for High Field MR Imaging
Jiang Zhu 1,2 , Eirc Gale 1 , Iliyana Atanasova 3 , and Peter Caravan 1
1
Martinos Center for Biomedical Imaging,
Charlestown, MA, United States,
2
Sichuan
Key laboratory of Medical Imaging, Nanchong, Sichuan,
China,
3
Massachusetts
Institute of Technology, Cambridge, MA, United States
Here we describe the synthesis and characterization of a
hexameric Mn(II)-based MR contrast agent. The hydration
state and other kinetic and thermodynamic parameters
were determined by 17O NMR method. The small, compact
size of this hexamer exhibits greater relaxivity at low,
intermediate and high fields compared to its monomeric
analog.The intermediate
R
and relatively rapid water exchange rate make this
Mn-EDTA multimer a good candiate for high-field MRI
contrast agent applications.
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