Specific alveolar macrophage targeting in LPS-induced COPD animal model using a free-breathing noninvasive MR imaging protocol coupled with the use of antibody-conjugated SPIO nanoparticles
Achraf Al Faraj 1 , Asma Sultana Shaik 1 , and Rabih Halwani 2
Radiological Sciences, King Saud University,
Riyadh, Riyadh, Saudi Arabia,
King Saud University, Riyadh, Riyadh, Saudi Arabia
In order to improve the identification and long-term
care for patients with COPD, new techniques are required
for better assessment of morphological and functional
impairment and contribution of each aspect to the
patients symptoms. Therefore, a noninvasive imaging
modality that enables in vivo inflammatory single cell
population detection to understand the physiological
process in COPD is highly required for both diagnostic
purposes and therapeutic applications.
Antibody-conjugated iron oxide magnetic nanoparticles
were developed to allow noninvasive targeting of a
specific alveolar macrophage subpopulation in the lung
of a LPS-induced COPD animal model using a
free-breathing UTE radial MR imaging protocol and
simultaneously detect the inflammation progression.
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