semi-LASER 1 H MR Spectroscopy at 7T in Human Brain: Metabolite Quantification Incorporating Subject-Specific Macromolecule Removal
Jacob Penner 1,2 and Robert Bartha 1,2
Centre for Functional and Metabolic Mapping,
Robarts Research Institute, London, Ontario, Canada,
Biophysics, Western University, London, Ontario, Canada
Magnetic resonance spectroscopy suffers from inherent
low sensitivity; it is advantageous to increase the
magnetic field strength and therefore the
signal-to-noise ratio. The purpose of this study was to
develop a 7 Tesla in vivo short echo time semi-LASER MR
spectroscopy protocol incorporating subject-specific
macromolecule removal, yielding absolute metabolite
concentrations. MRS data were obtained from the
parietal-occipital region of five young healthy
volunteers. Absolute levels were in good agreement with
previous studies that reported in vivo metabolite
concentrations at 7 Tesla in young healthy subjects.
Therefore, this protocol is suitable for measuring
metabolic changes in neuropathological conditions.
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