Evaluation of 2D L-COSY to study lipid composition in mouse fatty liver at 7T
Dimitri MARTEL 1 , Jean-Baptiste Langlois 2 , Denis Friboulet 1 , Olivier Beuf 1 , and Hlne Ratiney 1
CREATIS; CNRS UMR 5220 ; INSERM U1044 ;
Universit Lyon 1 ; INSA Lyon, Villeurbanne, France,
du Vivant, Bron, France
Recent studies have demonstrated the ability of 1D MRS
to assess in vivo hepatic fatty composition. In this
study, we evaluate the use of the 2D Localized
Correlation Spectroscopy (LCOSY) to analyze lipid
composition of fatty liver of ob/ob mice and compare it
to 1D MRS . Our results show that LCOSY can be used for
the study of fatty liver to derive quantitative indexes
in a more robust way than 1D MRS.
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