Abstract #2883
Toward field independent quantitative MRS
Anders Tisell 1,2 and Peter Lundberg 1,2
1
Radiation Physics, Department of Medicine
and Healths Sciences, Linkping University, Linkping,
Sweden,
2
Centre
for Medical Image Science and Visualization (CMIV),
Linkping University, Linkping, Sweden
Quantitative Magnetic Resonance Spectroscopy (qMRS)
provides direct information of the metabolic status of
the investigated tissue. Unfortunately, most current
approaches do not provide absolute metabolite
concentrations. Recently a method was proposed for
correction of the water relaxation effects based on the
use of quantitative MRI (qMRI). The purpose of the
present work was to investigate how large the
concentration differences were between such measurements
obtained using a 1.5 T system, or a 3.0 T MRI-scanner.
Moreover, another aim was to determine to what extent
the calibration method would improve the accuracy of the
determined concentrations, compared to conventional
water scaling. Using qMRI for calibration of the
internal water increased the accuracy of the estimated
metabolite concentrations significantly. Due to the
relative simplicity of such measurements we would
recommend such approach whenever absolute metabolite
concentrations are required.
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