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Abstract #2921

Skeletal muscle pH time course predicts water T2* during repeated exercise

Albrecht Ingo Schmid 1,2 , Kiril Schewzow 1,2 , Sigrun Goluch 1,2 , Georg Fiedler 1,2 , Fabian Niess 1,2 , Elmar Laistler 1,2 , Michael Wolzt 3 , Ewald Moser 1,2 , and Martin Meyerspeer 1,2

1 Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 2 MR Centre of Excellence, Medical University of Vienna, Vienna, Austria, 3 Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Vienna, Austria

During exercise, skeletal muscle T2* relaxation times are known to change. In this study, repeated EPI and localised 31P MRS were acquired in healthy volunteers at 7 T in one scanning session. A highly significant cross correlation (R2 = 0.720.16) between EPI signal and intracellular pH was found during 5 min. of plantar flexion exercise. Apparently T2* changes during exercise are driven by pH-dependent cellular water shift.

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