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Abstract #2967

Anatomically matched MRS voxel reveal NAA concentration differences between cortical gray and corpus callosum white matter in the mouse brain

Juergen Baudewig 1 , Juergen Finsterbusch 2 , and Susann Boretius 1

1 Section Biomedical Imaging, Department of Radiology and Neuroradiology, Christian-Albrechts-University, Kiel, Germany, 2 Dept. of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

In mice the cuboidal shape of voxels in classical localized proton MR spectroscopy (MRS) in combination the low fraction of white matter in mice hinders an exclusive quantification of metabolites from white matter structures. Here we used a recently developed localization method based on 2D-selective RF excitations to measure the corpus callosum and cortical gray matter to compare their NAA concentrations. Reduced NAA values in white matter compared in gray matter structures of mice were found. 2DRF excitations in MRS to acquire anatomically defined volumes in mice brain are a promising tool to improve the specificity of MRS.

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