Abstract #3029
Naturalistic fMRI of Clinical Computerized Paired Associate Learning Test with Visual Feedback of Hand Position
Mahta Karimpoor 1,2 , Fred Tam 3 , Tom Schweizer 4,5 , Corinne Fischer 6,7 , and Simon Graham 1,2
1
Physical Sciences, Sunnybrook Research
Institute, Toronto, Ontario, Canada,
2
Medical
Biophysics, University of Toronto, Toronto, Ontario,
Canada,
3
Medical
Biophysics, Sunnybrook Research Institute, Toronto,
Ontario, Canada,
4
Neurosurgery,
Keenan Research Centre in the Li Ka Shing Knowledge
Institute, Toronto, Ontario, Canada,
5
Neuroscience
Research Program, St. Michael's Hospital, Toronto,
Ontario, Canada,
6
Keenan
Research Centre in the Li Ka Shing Knowledge Institute,
Toronto, Ontario, Canada,
7
Geriatric
Psychiatry, St. Michael's Hospital, Toronto, Ontario,
Canada
Neuropsychological (NP) tests are commonly used to
detect abnormal brain function. Functional MRI may help
to characterize brain activity underlying NP test
performance, toward increasing test sensitivity and
specificity. Here, we refine an fMRI-compatible tablet
device for studying NP tests which require a touch
screen computer. Using the paired associates learning
(PAL) NP test as an example, it is shown that
integrating video data to provide users with visual
feedback of hand position during tablet responses,
instead of having them rely primarily on proprioceptive
inputs, produces activation maps where the learning and
memory contributions to PAL are more readily identified.
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