Validation of the temporal signal change caused by acupuncture stimulation with Multi-band acquisition .
Tomokazu Murase 1 , Masahiro Umeda 2 , Masaki Fukunaga 3 , Katsuya Maruyama 4 , Yuko Kawai 2 , Yasuharu Watanabe 2 , Chuzo Tanaka 1 , and Toshihiro Higuchi 1
Neurosurgery, Meiji University of Integrated
Medicine, Nantan-shi, Kyoto, Japan,
Informatics, Meiji University of Integrated Medicine,
Imaging, Immunology Frontier Research Center, Osaka
University, Osaka, Japan,
Siemens Japan K.K., Tokyo, Japan
We used MB-EPI and deconvolution analysis to examine the
temporal signal change, at a high time resolution, in
brain activity caused by acupuncture stimulation. For
statistical analysis, 3dDeconvolve, which is part of the
AFNI package, was used to extract the impulse response
functions (IRFs) of the fMRI signals on a voxel-wise
basis. Delayed and long-sustained increases of the
signal induced by the real acupuncture were observed
after stimulation. Especially, in real acupuncture,
significantly delayed and long-sustained increases of
BOLD signals were observed in several brain regions
related to pain perception than those observed in sham
acupuncture and palm scrubbing.
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