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Abstract #3044

Auditory fMRI study of frequency-modulation direction selectivity in the rat subcortex

Joe S. Cheng 1,2 , Jevin W. Zhang 1,2 , Patrick P. Gao 1,2 , Adrian Tsang 1,2 , Iris Y. Zhou 1,2 , and Ed X. Wu 1,3

1 Department of Electrical and Electronic Engineering, the University of Hong Kong, Hong Kong, Hong Kong, 2 Laboratory of Biomedical Imaging and Signal Processing, the University of Hong Kong, Hong Kong, Hong Kong, Hong Kong, 3 Laboratory of Biomedical Imaging and Signal Processing, the University of Hong Kong, hong kong, Hong Kong, Hong Kong

The direction of frequency-modulation (FM) sweep is an important acoustic cue for human language and animal vocal communications. To investigate FM direction processing in development and disease models, an in vivo and non-invasive technique with high spatial resolution is desired. Therefore, we investigated the FM direction selectivity in the rat subcortex using. The BOLD signal changes during upward sweeps were significantly higher than those during downward sweeps in the dorsal CIC, while dorsal nuclei of later lemniscus didnt show any directional selectivity. Therefore, fMRI proves a feasible tool to probe the FM sweep direction selectivity in the subcortical structures.

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