Is heart rate variability a hidden factor in resting-state functional connectivity?
Chantal Delon-Martin 1,2 , Hugo Lafaye de Micheaux 1,2 , Sonia Pellissier 1,3 , Amandine Rubio 2,4 , Bruno Bonaz 1,5 , and Sophie Achard 6
U836, INSERM, Grenoble Cdex 9, France,
UJF, Grenoble, France,
Universit de Savoie, Le Bourget du Lac, France,
pdiatrique, CHU, Grenoble, France,
CHU, Grenoble, France,
CNRS, Grenoble, France
Aim : Does autonomic nervous system impact on
resting-state functional connectivity ? Methods : We
acquired the heart rate variability as a measure of ANS
simultaneously with rs-fcMRI. We measured the
correlation between LF-component of HRV and each region
time-course. We measured the HRV impact on the
connectivity of each region with all other regions.
Results : We evidenced that the HRV correlates
negatively with the time-course of brain regions and
biases the connectivity measures between brain regions.
Conclusion : In rs-fcMRI, the impact of ANS has to be
taken into account for proper interpretation of results
from group studies.
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