Differences in resting state fMRI in rat under five different anesthetics
Jaakko Paasonen 1 , Raimo Salo 1 , Joanna K Huttunen 1 , and Olli Grhn 1
Department of Neurobiology, A.I.Virtanen
Institute for Molecular Sciences, University of Eastern
Finland, Kuopio, Finland
Resting state fMRI is an attractive tool in preclinical
research, but translational value of results may be
hindered by anesthesia. Our aim was to investigate the
possible differences in the resting state of rat brain
under five different anesthetics. Data were measured
from n = 52 rats and analyzed with independent component
analysis. Three cortical and one striatal component were
chosen for further comparison. Significant spatial and
spectral differences were seen between groups in all
cortical components, but not in striatal component.
Therefore the anesthetic in animal resting state studies
should be carefully selected, especially when
investigating the cortical networks.
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