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Abstract #3082

Highest cross-hemisphere correlations of resting-state FMRI in the awake macaque exhibit high correspondence to the pattern of callosal synaptic connections

Hang Joon Jo 1 , Stephen J Gotts 2 , Brian E Russ 3 , David A Leopold 3 , and Peter A Bandettini 1

1 Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, United States, 2 Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, MD, United States, 3 Section on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, National Institute of Mental Health, MD, United States

In our previous study, we reported that the resting brain activity of one hemisphere was maximally correlated with locations close to the corresponding anatomical location in nearly half of the cortex in the human brain, locations which are strongly reminiscent of the locations of callosal connections revealed by horseradish peroxidase tracing in monkeys, particularly in occipital, temporal, and parietal cortex. To examine this phenomenon more directly in macaque monkeys, we present that the maximum correlations of resting-state FMRI for individual monkeys can reflect the locations of axonal connections that were revealed by the existing studies of anatomical tracing experiments.

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