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Abstract #3083

Altered Brain Connectivity during Abstinence in a rat model of Alcoholism investigated with MEMRI and rsfMRI

Wolfgang Weber-Fahr 1 , Claudia Falfn-Melgoza 1 , Marcus Meinhardt 2 , Sandra Dieter 2 , Santiago Canals 3 , Alexander Sartorius 1 , and Wolfgang Sommer 2

1 RG Translational Imaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 2 Department of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 3 CSIC-UMH, Instituto de Neurociencias, Sant Joan d'Alacant, Spain

In this study we aimed to investigate the brain networks in a rat model of alcohol abstinence with MEMRI and rsfMRI. 21 rats of which 11 underwent 8 weeks of Ethanol exposure were scanned after 2 week withdrawal at a 9.4T scanner. Additionally to rsfMRI; T1-maps were acquired for 12 rats before and after subcutanious osmotic Mn2+ pump implantation. ICA showed an increased interoceptive network component in the cingulate cortex of rats in withdrawal. Even though both methods rely on fundamentally different approaches, an overlapping area of increased Mn2+ uptake was found in the MEMRI data.

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