Trial-wise Investigation of Cerebral Blood Volume Change in Human Brain at 7T
Laurentius Huber 1 , Aneurin Kennerley 2 , Dimo Ivanov 3 , Claudine Gauthier 1 , Harald E. Mller 1 , and Robert Turner 1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
of Psychology, The University of Sheffield, United
and Neuroscience, Maastricht University, Netherlands
Inter-trial variation of stimulus-induced fMRI signal
response is investigated with respect to BOLD and its
underlying CBV changes with a recently developed
multi-echo VASO sequence. The most striking result is
that the post-stimulus CBV has a post stimulus
undershoot (PSU) followed by an overshoot in an
oscillating manner. The characteristic time course of
the well described BOLD PSU appears only after averaging
across trials. Mechanisms underlying inter-trial
variations can be investigated by means of correlating
several separate features of individual trials, e.g.
initial response vs. PSU amplitude.
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