Abstract #3097
Combining bimodal optogenetic control with BOLD fMRI for causal analysis of the cortico-thalamic circuitry
Florian Schmid 1 , Lydia Wachsmuth 1 , Miriam Schwalm 2 , Albrecht Stroh 2 , and Cornelius Faber 1
1
Department of Clinical Radiology, University
of Mnster, Mnster, Germany,
2
Research
Group Molecular Imaging and Optogenetics, Johannes
Gutenberg-University Mainz, Mainz, Germany
We utilize optogenetic tools for a temporally and
spatially defined modulation of components of the
cortico-thalamic and the thalamo-cortical neuronal
network in nave rats and use BOLD fMRI as a global,
noninvasive readout. Our results show positive BOLD
activation of S1 sensory cortex upon optogenetic
stimulation of S1 or the posterior thalamic nuclei
group, and negative BOLD response upon inhibitory
stimulation.
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