Abstract #3099
The Effect of Dissolved Oxygen on Relaxation Rates of Blood Plasma
Yuhan Ma 1 , Avery J.L. Berman 1 , and G. Bruce Pike 1,2
1
McConnell Brain Imaging Center, Montreal
Neurological Institute, McGill University, Montreal,
Quebec, Canada,
2
Hotchkiss
Brain Institute and Department of Radiology, University
of Calgary, Calgary, Alberta, Canada
We investigated the effect of dissolved oxygen in
arterial blood plasma on BOLD signal during the
hyperoxia calibrated BOLD method by examining the
relaxation rates of bovine blood plasma under various
partial pressures of oxygen. The R
1
of
plasma linearly increases with oxygen concentration,
whereas R
2
and
R
2
*
are
unaffected. Therefore, dissolved oxygen in arterial
plasma should not induce significant BOLD contrast
through R
2
and
R
2
*
effects.
This study verifies that under hyperoxia, BOLD signal
contrast arises from dHb in venous and capillary blood -
the fundamental basis of the calibrated BOLD method -
and not dissolved oxygen in arteries.
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