Full-brain Blood Volume, Oxygenation and Hematocrit Imaging using T1 and T2 Prepared Velocity Selective Labeling
Esben Thade Petersen 1,2 , Jill De Vis 1 , Thomas Alderliesten 3 , C.A.T. van den Berg 2 , and Jeroen Hendrikse 1
Department of Radiology, UMC, Utrecht,
of Radiotherapy, UMC, Utrecht, Netherlands,
of Neonatology, UMC, Utrecht, Netherlands
In this work we present a method which allows
simultaneous full brain measurement of blood-volume,
oxygenation and hematocrit. The sequence is based on a
T1 and T2 Prepared Velocity Selective Labeling Module.
Blood oxygen saturation is an important parameter in
neuroscience and for the management of diseases such as
stroke or cancer. The sequence was tested using a
hypercapnic challenge, which alters the oxygenation
levels across the brain. Initial results are promising
and further validation work is ongoing in healthy
subjects using the reactivity challenge while
simultaneously monitoring frontal lobe oxygenation by
means of Near InfraRed Spectroscopy.
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