Abstract #3125
In vivo quantification of myowater anatomical compartmentation with proton T2-relaxation studies using a three site two exchange (3S2X) model
Ericky C.A. Araujo 1 , Yves Fromes 2 , and Pierre G Carlier 1
1
AIM-CEA Institut de Myologie, Laboratoire
RMN, Paris, France,
2
Universit
Pierre et Marie Curie Paris 6, Paris, France
Confirmation of the anatomical compartmentation theory
to explain the biexponential T2-relaxation of bulk-water
in skeletal muscle is motivated by the great clinical
interest on a non-invasive tool for quantification of
myowater distribution in vivo. In vivo T2-relaxation
data were acquired from the soleus of healthy volunteers
at different vascular filling conditions
(vascular-draining, normal and vascular-filling).
Variations on T2-spectra following the different
vascular conditions offered strong evidences in favour
of the anatomical compartmentation theory. Data were
analysed by means of compartmental exchange analysis. A
3S2X model has been shown to be capable of predicting
NMR relaxation data for realistic transmembrane exchange
values.
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