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Abstract #3128

Regularized, Joint Estimation of T 1 and M 0 Maps

Gopal Nataraj 1 , Jon-Fredrik Nielson 2,3 , and Jeffrey A. Fessler 1,2

1 Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI: Michigan, United States, 2 Biomedical Engineering, University of Michigan, Ann Arbor, MI: Michigan, United States, 3 Functional MRI Laboratory, University of Michigan, Ann Arbor, MI: Michigan, United States

We have developed a model-based approach for joint reconstruction of spin-lattice relaxation time T 1 and proton density M 0 maps from DESPOT1 sequences. Our statistical methods employ regularization to reduce noise amplification issues common in conventional least-squares estimators. The proposed technique dramatically improves mapping precision and quality, both for synthetic and in vivo data, and at a wide range of noise thresholds and flip angle combinations.

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