Multi-Component Fitting of T 2 * Relaxation in White Matter at 3 and 7 Tesla
Erika P. Raven 1 , Peter van Gelderen 2 , Xiaozhen Li 2 , Jacco A. de Zwart 2 , John VanMeter 3,4 , and Jeff H. Duyn 2
Neuroscience, Georgetown University,
Washington, DC, United States,
MRI section, LFMI, NINDS, National Institutes of Health,
Bethesda, MD, United States,
Georgetown University, Washington, DC, United States,
Center for Functional and Molecular Imaging, Washington,
DC, United States
Previous studies have demonstrated separation of
cellular compartments by utilizing large, local
frequency shifts (Δf) and increased T
at high magnetic field strength (7 T). This abstract
examines the reproducibility of a multi-component
fitting model at 7 T, while also investigating the
feasibility of this method at 3 T. Our findings suggest
the possibility of separating cellular specific
contributions in white matter at both 3 and 7 T.
Quantification of cellular compartments, importantly the
myelin-water fraction, has important implications for
the study of normal aging and disease.
This abstract and the presentation materials are available to members only;
a login is required.