Investigating white matter microstructural changes during demyelination using GRE phase and R2*
Way Cherng Chen 1,2 , Karla Miller 2 , and Kai-Hsiang Chuang 1
Singapore Bioimaging Consortium, Singapore,
University of Oxford, Oxford, Oxon, United Kingdom
The relationship between white matter microstructure and
GRE signal phase and magnitude was investigated using a
cuprizone mouse model of demyelination. Ex vivo R2* and
frequency maps showed high correlations with
histological myelin stain intensity. Geometric WM
modeling suggested that the GRE signal is not only
sensitive to the bulk amount of myelin but also the
spatial distribution of myelin within WM.
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