Real time changes of phase contrast of gray matter and white matter between in vivo and in situ postmortem rat brain
Jie Luo 1 and Dmitriy Yablonskiy 1
Radiology, Washington University in St.
Louis, St. Louis, MO, United States
The phase contrasts obtained by gradient echo MRI
provides complimentary information on brain anatomy. One
of the ways to understanding the biophysical origins of
the phase contrast relies on postmortem studies.
However, to what extend and how fast postmortem changes
affect MR tissue properties are not known. In this pilot
study, we have demonstrated for the first time changes
in the gray/white matter phase contrast and R2* during
transition from live to postmortem conditions. Our data
are in agreement with minor role of blood oxygenation
level on gray/white matter phase contrast and major role
on changes in R2* contrast.
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