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Abstract #3217

Temperature and fixation correction for postmortem MRI of the brain

Christoph Birkl 1 , Christian Langkammer 1 , Johannes Haybaeck 2 , Christina Ernst 2 , Johannes Petzold 2 , Franz Fazekas 1 , and Stefan Ropele 1

1 Department of Neurology, Medical University of Graz, Graz, Austria, 2 Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria

Tissue fixation with formaldehyde can significantly affects the relaxation properties of the underlying tissue which hinders direct comparison with in vivo conditions. We here present a simple correction scheme that is based on the temperature dependency of T1, T2 and T2* in fixed and unfixed tissue. The proposed correction scheme was validated with corresponding fixed and unfixed data from literature.

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