Temperature and fixation correction for postmortem MRI of the brain
Christoph Birkl 1 , Christian Langkammer 1 , Johannes Haybaeck 2 , Christina Ernst 2 , Johannes Petzold 2 , Franz Fazekas 1 , and Stefan Ropele 1
Department of Neurology, Medical University
of Graz, Graz, Austria,
of Neuropathology, Institute of Pathology, Medical
University of Graz, Graz, Austria
Tissue fixation with formaldehyde can significantly
affects the relaxation properties of the underlying
tissue which hinders direct comparison with in vivo
conditions. We here present a simple correction scheme
that is based on the temperature dependency of T1, T2
and T2* in fixed and unfixed tissue. The proposed
correction scheme was validated with corresponding fixed
and unfixed data from literature.
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