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Abstract #3226

Combined Effects of Albumin and Manganese on 1H Relaxation Rates of aCSF

L. Sorina Truica 1 , J. Keiko McCreary 1 , Adam R. Neumann 1 , Maurice A. Needham 1 , Albert R. Cross 1 , and Ian Q. Whishaw 1

1 Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada

The use of manganese (Mn) as a contrast agent for neuro-anatomical and functional mapping has been studied in animal models for the last decade. Mn contrast enhancement is directly proportional to the changes in relaxation rates in brain tissue. However, the binding of Mn to proteins may alter its relaxation. Thus protein levels and metabolic processes that produce them in the brain and cerebrospinal fluid (CSF) will alter Mn contrast. The aim of this study was to investigate the relaxation rate of Mn in artificial CSF (aCSF), when different levels of protein are present. We found that the concentration of protein used affected both the T1 and T2 relaxation times.

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