Validations of Quantitative Susceptibility Mapping in Excised Human Cerebral Cavernous Malformation Lesions and in Mice
Huan Tan 1 , Changbin Shi 1 , Abdul Ghani Mikati 1 , Robert Shenkar 1 , Tian Liu 2 , Yi Wang 3,4 , Pottumarthi V Prasad 1,5 , Robert R Edelman 5,6 , and Issam Awad 1
University of Chicago, Chicago, IL, United
LLC, New York, NY, United States,
Cornell Medical College, New York, NY, United States,
University, Ithaca, NY, United States,
University HealthSystem, Evanston, IL, United States,
University Feinberg School of Medicine, Chicago, IL,
In this study, we validated quantitative susceptibility
mapping (QSM) in two ex-vivo studies. First, we
correlated QSM results in human cerebral cavernous
malformation (CCM) lesion specimens against mass
spectroscopy. Second, we compared lesional
susceptibility distribution with histology in CCM mice.
The preliminary results demonstrated the excellent
sensitivity and specificity of QSM to identify and
quantify lesional iron content in CCM.
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