Meeting Banner
Abstract #3275

Validations of Quantitative Susceptibility Mapping in Excised Human Cerebral Cavernous Malformation Lesions and in Mice

Huan Tan 1 , Changbin Shi 1 , Abdul Ghani Mikati 1 , Robert Shenkar 1 , Tian Liu 2 , Yi Wang 3,4 , Pottumarthi V Prasad 1,5 , Robert R Edelman 5,6 , and Issam Awad 1

1 University of Chicago, Chicago, IL, United States, 2 MedImageMetric LLC, New York, NY, United States, 3 Weill Cornell Medical College, New York, NY, United States, 4 Cornell University, Ithaca, NY, United States, 5 NorthShore University HealthSystem, Evanston, IL, United States, 6 Northwestern University Feinberg School of Medicine, Chicago, IL, United States

In this study, we validated quantitative susceptibility mapping (QSM) in two ex-vivo studies. First, we correlated QSM results in human cerebral cavernous malformation (CCM) lesion specimens against mass spectroscopy. Second, we compared lesional susceptibility distribution with histology in CCM mice. The preliminary results demonstrated the excellent sensitivity and specificity of QSM to identify and quantify lesional iron content in CCM.

This abstract and the presentation materials are available to members only; a login is required.

Join Here