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Abstract #3294

Using Simultaneous Multi-Slice Excitation to Accelerate CEST Imaging

Dapeng Liu 1,2 , Rong Xue 1,2 , Jinyuan Zhou 3,4 , Jing An 5 , Xinyuan Miao 1 , and Danny JJ Wang 2,6

1 State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2 UCLA-Beijing Joint Center for Advanced Brain Imaging, Beijing, China and Los Angeles, California, United States, 3 Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 4 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5 Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 6 Department of Neurology, University of California Los Angeles, Los Angeles, United States

Chemical exchange saturation transfer (CEST) imaging is a novel MRI technique that can detect low-concentration solutes in tissue compared to routine water MR images. However, a long scan time due to multiple repetitions required to acquire a full frequency spectrum or to increase signal-to-noise ratios and a long saturation pulse (or pulse train) have restricted its practical clinical application that typically needs multi-slice measurements. Here we present an efficient and accelerated CEST imaging technique using a simultaneous multi-slice (SMS) excitation Turbo-FLASH (TFL) sequence in human brain at 3 T.

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