Abstract #3308
Isolation of CEST contrasts from asymmetric MT effects in a human brain
Jae-Seung Lee 1,2 , Ding Xia 1 , Yulin Ge 1 , Alexej Jershow 2 , and Ravinder Regatte 1
1
Radiology, New York University, New York,
NY, United States,
2
Chemistry,
New York University, New York, NY, United States
Chemical exchange saturation transfer (CEST) has great
potential to enhance the detection of exchangeable
proton species such as low concentrations of metabolites
in
vivo
brain.
However, CEST effects are often masked by asymmetric
magnetization transfer (MT) effects from macromolecules
in tissues and organs. Here, we show that the asymmetry
of MT effects in the brain is large enough to overshadow
the CEST effects and that the so-called uniform-MT (uMT)
method may be useful to reveal the genuine CEST
contrast.
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