Molecular Imaging of Fibrotic Remodeling and Functional Microcirculation using a novel MT/CEST Encoded Steady State Cardiac Cine MRI Pulse Sequence.
Moriel Vandsburger 1 , Katrien Vandoorne 2 , Roni Oren 2 , Avigdor Leftin 2 , and Michal Neeman 2
Physiology and Saha Cardiovascular Research
Center, University of Kentucky, Lexington, Kentucky,
Institute of Science, Rehovot, Israel
Molecular imaging of the heart is critical for detection
of early signs of disease and for monitoring response to
therapy. We present the development of a steady state
retrospectively gated cardiac cine imaging sequence in
which the presence of fibrosis or CEST contrast agents
was encoded into the myocardial signal intensity. We
applied this technique for quantification of fibrotic
scar formation in the mouse heart after myocardial
infarction, and for imaging of the myocardial
microcirculation following intravenous injection of a
CEST contrast agent. Since contrast from each target is
selectively encoded, this technique can potentially
enable multiplexed imaging of multiple molecular targets
at high-resolution in the heart.
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